Here are a few more signs that have peaked my interest:
Henderson's Drugs in Penn Yan, NY, founded in 1956. They have four other locations (Geneva, Montour Falls, Seneca Falls, and Syracuse). This one has the most interesting signage.
Brown Derby in Poughkeepsie, NY, is a restaurant that opened in 1902. In recent years, it was known as 96 Main but new owners have changed the name back to the original.
Don't forget - I invite you to send me a picture (.jpg file) of the favorite sign you've encountered on your travels--whether it is still an operating business or not. send it to: email@example.com.